Uncle Hub from Secondhand Lions EDIT- Oops. I missed the part where it said 'game'. In that case, Kyle Katarn.
Bill Laimbeer. I defy you to give me a game title better than "Bill Laimbeer's Combat Basketball". A game in which the only liscensed player was Bill Laimbeer and you played a futuristic basketball that allowed you to beat the shit out of your cyborg opponents. Also the bad dudez from Bad Dudez weren't bad either.
Megaman. I defy you to name a hero who destroys entire armies armed with a robot dog, a robot bird, a robot cat, and an arm-mounted cannon with musically-themed names.